Detest first couple of lowbrow articles (6)
I believe the answer is:
loathe
'detest' is the definition.
(loathing is a kind of detesting)
'first couple of lowbrow articles' is the wordplay.
'first' is a charade indicator (letters next to each other).
'couple of lowbrow' becomes 'lo' (I can't explain this - if you can you should believe this answer much more).
'articles' becomes 'athe' (two examples of the part-of-speech: a+the).
'lo' put next to 'athe' is 'LOATHE'.
(Other definitions for loathe that I've seen before include "To heal (anag)" , "Strongly detest" , "Greatly hate" , "dislike, to a great extent" , "Cordially dislike, despise" .)