Detest hotel at end of avenue (4)
I believe the answer is:
hate
'detest' is the definition.
(synonyms)
'hotel at end of avenue' is the wordplay.
'hotel' becomes 'h' (phonetic alphabet: alpha, bravo, charlie etc.).
'end of' indicates one should take the final letters.
The final letter of 'avenue' is 'e'.
'h'+'at'+'e'='HATE'
(Other definitions for hate that I've seen before include "Intense dislike" , "Despise" , "Extreme dislike" , "Strong aversion" , "Antipathy" .)