Detest resident in chateau (4)
I believe the answer is:
hate
'detest' is the definition.
(synonyms)
'resident in chateau' is the wordplay.
'resident' says the answer is hidden in the clue (I've seen 'resident of' mean this).
'HATE' can be found hidden inside 'in chateau'.
(Other definitions for hate that I've seen before include "Antipathy" , "Odium" , "Dislike intensely" , "Fury" , "Extreme dislike" .)