Detrimental (7)
I believe the answer is:
adverse
'detrimental' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for adverse that I've seen before include "Unfavourable - red vase (anag)" , "Opposed - inauspicious - opposite" , "Dire" , "Unfavourable to evaders" , "In an opposing direction" .)