Deviation put reader off
I believe the answer is:
departure
'deviation' is the definition.
(synonyms)
'put reader off' is the wordplay.
'off' indicates an anagram.
'put'+'reader'='putreader'
'putreader' with letters rearranged gives 'DEPARTURE'.
(Other definitions for departure that I've seen before include "Act of leaving" , "Exodus" , "Variation from the expected" , "outbound journey?" , "Exit" .)