Different ending in strange intense feeling (8)
I believe the answer is:
sentient
'feeling' is the definition.
(synonyms)
'different ending in strange intense' is the wordplay.
'ending' says to take the final letters (the ending of the word).
'in' is an insertion indicator.
'strange' is an anagram indicator.
The last letter of 'different' is 't'.
'intense' is an anagram of 'senient'.
't' put into 'senient' is 'SENTIENT'.
(Other definitions for sentient that I've seen before include "having power of perception" , "Endowed with feeling and consciousness" , "Feeling, conscious" , "Having feelings" , "Capable of feeling and perceiving things" .)