Different in Rotherham (5)
I believe the answer is:
other
'different' is the definition.
(similar in meaning)
'in rotherham' is the wordplay.
'in' indicates a hidden word.
'OTHER' is hidden within 'rotherham'.
(Other definitions for other that I've seen before include "Different, alternative" , "Different, not the same one or this one" , "Different; additional" , "Second" , "Throe (anag)" .)