Different route further from the centre (5)
I believe the answer is:
outer
'further from the centre' is the definition.
(I've seen this before)
'different route' is the wordplay.
'different' is an anagram indicator (letters placed in a different order).
'route' is an anagram of 'OUTER'.
(Other definitions for outer that I've seen before include "Away from the centre" , "Objective" , "External kind of route" , "Archer's shot" , "Poor shot" .)