Difficult situation for two women, about 50 (7)
I believe the answer is:
dilemma
'difficult situation' is the definition.
(I've seen this before)
'two women about 50' is the wordplay.
'two women' means two replacements for 'woman'.
'woman' becomes 'di' (short for Diana).
'woman' becomes 'emma' ().
'about' means one lot of letters go next to another.
'50' becomes 'l' (Roman numeral).
'emma' after 'l' is 'lemma'.
'di'+'lemma'='DILEMMA'
'for' acts as a link.
(Other definitions for dilemma that I've seen before include "Difficult problem" , "Difficult choice; quandary" , "Difficulty (with two choices?)" , "Catch-22" , "Difficult-choice situation" .)