Difficulty caused by stinging sensation right away (6)
I believe the answer is:
pickle
'difficulty' is the definition.
(pickle can informally mean a difficult situation)
'stinging sensation right away' is the wordplay.
'stinging sensation' becomes 'prickle' (I've seen this before).
'right' becomes 'r' (abbreviation).
'away' suggests deleting specific letters.
'prickle' with 'r' taken out is 'PICKLE'.
'caused by' is the link.
(Other definitions for pickle that I've seen before include "tight spot" , "tricky spot" , "A preserved vegetable or a fine mess" , "Condiment - tricky situation - troublesome child" , "Preserve in brine or vinegar" .)