Difficulty, disadvantage (4)
I believe the answer is:
snag
I believe this clue is a double definition.
'difficulty' is the first definition.
(I know that snag is a type of problem)
'disadvantage' is the second definition.
(I've seen this in another clue)
(Other definitions for snag that I've seen before include "Rip or tear" , "Catch - disadvantage" , "Slight problem" , "banger down under" , "Catch -- problem" .)