Dire peril (6)
I believe the answer is:
danger
'peril' is the definition.
(synonyms)
I don't understand how the rest of the clue works.
(Other definitions for danger that I've seen before include "Peril, exposure to harm" , "'Peril, risk (6)'" , "Peril in garde" , "Garden (anag) - peril" , "Peril, jeopardy" .)