Dire stew cooked up, most odd (8)
I believe the answer is:
weirdest
'most odd' is the definition.
(I've seen this before)
'dire stew cooked up' is the wordplay.
'cooked up' indicates an anagram.
'dire'+'stew'='direstew'
'direstew' is an anagram of 'WEIRDEST'.
(Other definitions for weirdest that I've seen before include "Most unearthly" , "Most strikingly odd" , "Most bizarre" , "Most uncanny!" .)