Direct someone in a star role (4)
I believe the answer is:
lead
I believe this is a quadruple definition!!
'direct' is the first definition.
(synonyms)
'someone' is the second definition.
(lead is a kind of someone)
'in' acts as a link.
'a star' is the third definition.
('lead' can be a synonym of 'star')
'role' is the fourth definition.
(thesaurus)
(Other definitions for lead that I've seen before include "shot maybe" , "Live" , "Guide,direct" , "chain" , "most important story" .)