Direction, perhaps north, to retreat and run away (5)
I believe the answer is:
elope
'run away' is the definition.
(I've seen this before)
I can't explain the remainder of the clue.
Can you help me to learn more?
(Other definitions for elope that I've seen before include "Run away to get married" , "Flee to wed" , "Bolt" , "Do a runner" , "go off to the match?" .)