Dirty family man cleared out again (7)
I believe the answer is:
unclean
'dirty' is the definition.
(I know that dirty can be written as unclean)
'family man cleared out again' is the wordplay.
'family man' becomes 'uncle' (I've seen this in another clue).
'cleared out' says to hollow out the word (remove centre letters).
'again' with its middle removed is 'an'.
'uncle'+'an'='UNCLEAN'
(Other definitions for unclean that I've seen before include "(Ritually) tainted" , "Dirty, ritually impure" , "Defiled" , "Filthy" , "Dirty; immoral" .)