Dirty kinsman gutted again (7)
I believe the answer is:
unclean
'dirty' is the definition.
(I know that dirty can be written as unclean)
'kinsman gutted again' is the wordplay.
'kinsman' becomes 'uncle' (uncle is a kind of kinsman).
'gutted' means to remove the middle letters (to gut something is to remove its insides).
'again' with its middle removed is 'an'.
'uncle'+'an'='UNCLEAN'
(Other definitions for unclean that I've seen before include "Infected" , "taboo" , "Dirty, needs a wash" , "Dirty or unwashed" , "(Ritually) tainted" .)