Disaster or misfortune (8)
I believe the answer is:
calamity
This clue is a double definition.
'disaster' is the first definition.
(I know that disaster can be written as calamity)
'misfortune' is the second definition.
(calamity is a kind of misfortune)
(Other definitions for calamity that I've seen before include "Disaster for wild west Jane" , "15 [JANE] the frontierswoman" , "Martha Jane Cannary" , "Musical set in Deadwood" , "Catastrophe" .)