Discontinue with article on church in the middle of Vaucluse (6)
I believe the answer is:
cancel
'discontinue' is the definition.
(I've seen this before)
'article on church in the middle of vaucluse' is the wordplay.
'article' becomes 'an' (indefinite article).
'on' says to put letters next to each other.
'church' becomes 'ce' (abbreviation for Church of England).
'in the' means one lot of letters goes inside another.
'middle of' indicates the central letters.
The centre of 'vaucluse' is 'cl'.
'an'+'ce'='ance'
'ance' going inside 'cl' is 'CANCEL'.
'with' acts as a link.
(Other definitions for cancel that I've seen before include "Annul, revoke" , "Strike out" , "stop?" , "Discontinue" , "Annul; negate" .)