Discriminating, but comfortable around house (6)
I believe the answer is:
choosy
'discriminating' is the definition.
(thesaurus)
'comfortable around house' is the wordplay.
'comfortable' becomes 'cosy' ('cosy' can be similar in meaning to 'comfortable').
'around' indicates putting letters inside.
'house' becomes 'ho' (abbreviation for house).
'cosy' placed around 'ho' is 'CHOOSY'.
'but' acts as a link.
(Other definitions for choosy that I've seen before include "Selective" , "Overly fastidious" , "Picky or particular" , "Discriminating" , "Fastidious (colloq.)" .)