Disfigure 500 from east badly (6)
I believe the answer is:
deform
'disfigure' is the definition.
(I've seen this in another clue)
'500 from east badly' is the wordplay.
'500' becomes 'D' (Roman numeral for 500).
'east' becomes 'E' (synonyms).
'badly' is an anagram indicator.
'from'+'e'='frome'
'frome' with letters rearranged gives 'eform'.
'd'+'eform'='DEFORM'
(Other definitions for deform that I've seen before include "Distort out of shape" , "Spoil" , "Disfigure" , "Twist out of shape" , "Disorder" .)