Disgrace one left out of popular family (6)
I believe the answer is:
infamy
'disgrace' is the definition.
(thesaurus)
'one left out of popular family' is the wordplay.
I cannot really understand how this works, but
'one' could be 'i' (Roman numeral) and 'i' is located in the answer.
'family' could be 'fam' and 'fam' is found within the answer.
The remaining letters 'ny' is a valid word which might be clued in a way I don't see.
This explanation may well be incorrect...
(Other definitions for infamy that I've seen before include "dishonour" , "Ill-repute" , "Public disgrace" , "Villainous act" , "Bad reputation, notoriety" .)