Disheartened, throw accordion gently? It's sounding like a guitar (6)
I believe the answer is:
twangy
'sounding like a guitar' is the definition.
I don't know anything about this answer so I can't tell whether it can be defined by this definition.
'disheartened throw accordion gently?' is the wordplay.
'disheartened' means to remove the middle letters (the middle or heart is removed).
'accordion gently?' becomes 'angy' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'throw' with its middle taken out is 'tw'.
'tw'+'angy'='TWANGY'
'it's' is the link.
Can you help me to learn more?
(Other definitions for twangy that I've seen before include "Like the sound of a plucked string" , "Like guitar music" .)