Disinclined to meet a South American city seducer (8)
I believe the answer is:
lothario
'seducer' is the definition.
(thesaurus)
'disinclined to meet a south american city' is the wordplay.
'disinclined' becomes 'loth' ('loth' can be similar in meaning to 'disinclined').
'to meet' means one lot of letters go next to another.
'south american city' becomes 'rio' (I've seen this before).
'loth'+'a'+'rio'='LOTHARIO'
(Other definitions for lothario that I've seen before include "Who chases female" , "Fictional seducer" , "Libertine - ol' hot air (anag)" , "Womaniser, philanderer" , "Libertine or woman-chaser" .)