Disposable handkerchief - it's returned by small woman (6)
I believe the answer is:
tissue
'disposable handkerchief' is the definition.
(I've seen this before)
'it's returned by small woman' is the wordplay.
'returned' says the letters should be written in reverse.
'by' means one lot of letters go next to another.
'small' becomes 's' (abbreviation - e.g. clothes size).
'woman' becomes 'sue' (woman's name).
'it' back-to-front is 'ti'.
'ti'+'s'+'sue'='TISSUE'
(Other definitions for tissue that I've seen before include "'Soft, thin paper (6)'" , "Basic structural element of an animal or plant" , "A fabrication (of lies)" , "Type of paper" , "cellular network" .)