Dispose of little room, by the sound of it (4)
I believe the answer is:
sell
'dispose of' is the definition.
(I've seen this before)
'little room by the sound of it' is the wordplay.
'little room' becomes 'cell' (I've seen this before).
'by the sound of it' indicates a 'sounds like' (homophone) clue.
'cell' sounds like 'SELL'.
(Other definitions for sell that I've seen before include "Retail" , "Exchange goods etc. for money" , "Peddle" , "What shops do" , "Traffic" .)