Disquiet coming from misfortune, as expected (6)
I believe the answer is:
unease
'disquiet' is the definition.
('unease' can be a synonym of 'disquiet')
'coming from misfortune as expected' is the wordplay.
'coming from' indicates the answer is hidden within the clue.
'UNEASE' is hidden in the letters of 'misfortune as expected'.
(Other definitions for unease that I've seen before include "Disquiet" , "State of worry and lack of confidence" , "Anxiety, discontent" , "State of anxiety" , "Discomfort or apprehension" .)