Disregard poor region (6)
I believe the answer is:
ignore
'disregard' is the definition.
('ignore' can be a synonym of 'disregard')
'poor region' is the wordplay.
'poor' indicates anagramming the letters.
'region' with letters rearranged gives 'IGNORE'.
(Other definitions for ignore that I've seen before include "Send to Coventry" , "Fail to consider" , "Fail to notice (6)" , "Cut head off" , "Pay no attention to, disdain" .)