Disregard region's suffering (6)
I believe the answer is:
ignore
'disregard' is the definition.
('ignore' can be a synonym of 'disregard')
'region's suffering' is the wordplay.
'suffering' indicates an anagram.
'region' anagrammed gives 'IGNORE'.
(Other definitions for ignore that I've seen before include "Pay no heed to" , "Blank" , "Discount" , "Cut head off" , "Pay no attention to, disregard" .)