Disregard wild region (6)
I believe the answer is:
ignore
'disregard' is the definition.
(I know that disregard can be written as ignore)
'wild region' is the wordplay.
'wild' indicates an anagram.
'region' with letters rearranged gives 'IGNORE'.
(Other definitions for ignore that I've seen before include "Cut head off" , "Turn a blind eye to" , "Slight" , "set aside" , "Region (anag)" .)