Dissipated female locked up (8)
I believe the answer is:
misspent
'dissipated' is the definition.
(thesaurus)
'female locked up' is the wordplay.
'female' becomes 'miss' (miss is a kind of female).
'locked up' becomes 'pent' (I've seen this in other clues).
'miss'+'pent'='MISSPENT'
(Other definitions for misspent that I've seen before include "Dissipated" , "wasted away?" , "Passed the time unwisely, as a youth perhaps" , "troublesome youth?" , "Wasted (as youth)" .)