Distress, wretchedness (6)
I believe the answer is:
misery
I believe this is a double definition.
'distress' is the first definition.
(I've seen this in another clue)
'wretchedness' is the second definition.
(synonyms)
(Other definitions for misery that I've seen before include "Wretched state" , "Despair" , "Torment" , "Mental distress or discomfort" , "''. . . . . . loves company''" .)