Distressed to go down after being at university (5)
I believe the answer is:
upset
'distressed' is the definition.
(I know that distressed can be written as upset)
'go down after being at university' is the wordplay.
'go down' becomes 'set' (setting is a kind of going down).
'after' says to put letters next to each other.
'being at university' becomes 'up' (slang term meaning at university).
'set' after 'up' is 'UPSET'.
'to' is the link.
(Other definitions for upset that I've seen before include "Put out" , "Overturn - perturbed - disordered" , "Upheaval" , "Disturbed or capsized" , "Make unhappy; knock over" .)