Disturb emotionally with unusual setup (5)
I believe the answer is:
upset
'disturb emotionally' is the definition.
'upset' can be an answer for 'disturb' (synonyms). I'm unsure of the 'emotionally' bit.
'unusual setup' is the wordplay.
'unusual' is an anagram indicator.
'setup' is an anagram of 'UPSET'.
'with' is the link.
Can you help me to learn more?
(Other definitions for upset that I've seen before include "Knock over; worried" , "Unhappy - unexpected defeat" , "Disturb - spoil" , "Overturn, disturb" , "Put out" .)