Disturbed lone daughter of Icarius (8)
I believe the answer is:
penelope
'daughter of icarius' is the definition.
(Greek mythology)
'disturbed lone' is the wordplay.
I cannot quite see how this works, but
an anagram of 'lone' is 'nelo' which is within the answer.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for penelope that I've seen before include "Mrs Odysseus" , "Waiter" , "Woman" , "The wife who waited for years for Odysseus" , "lady" .)