Disturbing Calif if not in misery (10)
I believe the answer is:
affliction
'misery' is the definition.
(thesaurus)
'disturbing calif if not' is the wordplay.
'disturbing' indicates an anagram (I've seen this in other clues).
'calif'+'if'+'not'='calififnot'
'calififnot' anagrammed gives 'AFFLICTION'.
'in' is the link.
(Other definitions for affliction that I've seen before include "cause of severe distress" , "Cause of pain or harm" .)