Do first things first (5)
I believe the answer is:
start
'first' is the definition.
(I know that first can be written as start)
'do first things' is the wordplay.
'do' becomes 'star' (starring is a kind of doing).
'first things' becomes 't' (sst letter of 'things').
'star'+'t'='START'
(Other definitions for start that I've seen before include "Begin - jump" , "Jerk" , "open" , "Move quickly < when surprised" , "Beginning" .)