Do over grand lot in northern industrial town (10)
I believe the answer is:
darlington
'northern industrial town' is the definition.
(town in the north of England)
'do over grand lot in' is the wordplay.
'do' is an anagram indicator (solvers must work out or 'do' the anagram puzzle).
'over' is a charade indicator (letters next to each other).
'grand'+'lot'='grandlot'
'grandlot' put after 'in' is 'ingrandlot'.
'ingrandlot' is an anagram of 'DARLINGTON'.
(Other definitions for darlington that I've seen before include "Town near 24 [MARSKE]" , "Terminus of the world's first passenger railway" , "northern town" , "rail terminus" .)