Do your utmost and find a line of descent (6)
I believe the answer is:
strain
'line of descent' is the definition.
(thesaurus)
I don't understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for strain that I've seen before include "Music" , "Tension on trains" , "making a great demand on the emotions?" , "Screen" , "Great effort - sieve" .)