Doctor foretold extremes of Holmes' life in novel (4,2,3,5)
I believe the answer is:
lord of the flies
'novel' is the definition.
(I've seen this before)
'doctor foretold extremes of holmes' life' is the wordplay.
'doctor' indicates anagramming the letters.
'extremes of' means to remove the middle letters.
'holmes' with its middle removed is 'hs'.
'foretold'+'hs'+'life'='foretoldhslife'
'foretoldhslife' with letters rearranged gives 'LORD OF THE FLIES'.
'in' acts as a link.
(Other definitions for lord of the flies that I've seen before include "peer: he clocks up the air miles?" , "Novel" .)