Doctor got up and down (6)
I believe the answer is:
morose
'down' is the definition.
(both can mean sad)
'doctor got up' is the wordplay.
'doctor' becomes 'mo' (medical officer).
'got up' becomes 'rose' (past tense of 'raise').
'mo'+'rose'='MOROSE'
'and' acts as a link.
(Other definitions for morose that I've seen before include "Rarely" , "Sullen and gloomy" , "Sullen. bad-tempered" , "in gloomy mood" , "Melancholy" .)