Doctor in South American country with November issue (8)
I believe the answer is:
children
'issue' is the definition.
(I've seen this before)
'doctor in south american country with november' is the wordplay.
'doctor' becomes 'dr' ('Dr' can be a synonym of 'doctor'**).
'in' means one lot of letters goes inside another.
'south american country' becomes 'chile' (Chile is an example).
'with' says to put letters next to each other.
'november' becomes 'n' (phonetic alphabet: alpha, bravo, charlie etc.).
'dr' put within 'chile' is 'childre'.
'childre'+'n'='CHILDREN'
(Other definitions for children that I've seen before include "Issue" , "Young people" , "Offspring" , "Minors" , "Youngsters" .)