Doctors hate to interrupt men the worse for wear? (4-5)
I believe the answer is:
moth-eaten
'worse for wear?' is the definition.
(damaged by moths)
'doctors hate to interrupt men' is the wordplay.
'doctors' indicates anagramming the letters.
'interrupt' means one lot of letters goes inside another.
'hate'+'to'='hateto'
'hateto' with letters rearranged gives 'otheat'.
'otheat' put within 'men' is 'MOTH-EATEN'.
'the' acts as a link.
(Other definitions for moth-eaten that I've seen before include "Showing severe signs of wear and tear" , "Falling to bits" , "Tatty" , "Threadbare" , "Damaged by insects" .)