Doctrine leads to intolerance, spite and malice (3)
I believe the answer is:
ism
'doctrine' is the definition.
(suffix for disciplines or schools of thought)
'leads to intolerance spite and malice' is the wordplay.
'leads to' says to take the initial letters.
'and' means one lot of letters go next to another.
'malice' becomes 'm' (this might be a standard abbreviation of which I'm unaware).
The first letters of 'intolerance spite' is 'is'.
'is'+'m'='ISM'
Can you help me to learn more?
(Other definitions for ism that I've seen before include "Ideological movement" , "Stage performance of singing" , "Belief system" , "specific doctrine" , "Distinctive theory" .)