Does it mean nothing to males? (4)
I believe the answer is:
omen
'does it mean' is the definition.
I can't judge whether this definition defines the answer.
'nothing to males?' is the wordplay.
'nothing' becomes 'O' (O resembles 0).
'to males?' becomes 'men' (man is a kind of male).
'o'+'men'='OMEN'
Can you help me to learn more?
(Other definitions for omen that I've seen before include "Harbinger, prophetic sign" , "Forewarning, harbinger" , "Sign of likely future event" , "Foreshadow" , "Warning - sign" .)