Does their work make them go totally up the wall? (10)

'does' is the definition.
Although both the answer and definition are plural nouns, I can't see how they can define each other.

'their work make them go totally up the wall?' is the wordplay.
I cannot really see how this works, but
'go' could be 'last' ('last' can be a synonym of 'go') and 'last' is found in the answer.
This may be the basis of clue (or it may be nonsense).

Can you help me to learn more?