Dog in street, barking (6)
I believe the answer is:
setter
'dog' is the definition.
(setter is a type of dog)
'street barking' is the wordplay.
'barking' indicates an anagram (UK slang for mad).
'street' anagrammed gives 'SETTER'.
'in' is the link.
(Other definitions for setter that I've seen before include "Bird trained to scent game" , "Long-haired dog breed" , "One barking" , "I may pose a problem" , "That's what you call me?" .)