"Don't interfere!" (3,2,2)
(Other definitions for let it be that I've seen before include "Beatles record" , "Single" , "title?" , "Beatles song - don't interfere!" , "Beatles album" .)
'don't interfere' is the definition.
(I've seen this before)
This is the entire clue.
(Other definitions for hands-off that I've seen before include "With no manual input" , "Not involving any intervention" , "Don't touch!" .)