Don't take time off (5)
I believe the answer is:
leave
This clue is a double definition.
'don't take' is the first definition.
(I've seen this before)
'time off' is the second definition.
(leave is a kind of time off)
(Other definitions for leave that I've seen before include "Desert" , "Permission to go; allow to remain" , "Renounce" , "Permission - depart" , "Withdraw - permission - to go - holiday" .)