Doom affected temper (4)
I believe the answer is:
mood
'temper' is the definition.
(synonyms)
'doom affected' is the wordplay.
'affected' is an anagram indicator.
'doom' is an anagram of 'MOOD'.
(Other definitions for mood that I've seen before include "Disposition" , "Depression" , "Frame of mind" , "Bad feeling" , "Temporary state of mind" .)